There are two immediate problems with Chains. It’s possible, if you’re a regular user of Audacity to automate Effect > Equalization so much it stops working. That’s one reason Equalization as a formal effects tool vanished in the latest Audacity. The job didn’t go away, but how you get there did.
You can’t automate Noise Reduction. Full stop. Chains and Macros can’t automate decisions and you have to decide where the noise is for the Profile step.
There are theater corrections such as DeEssing, DeClicking, tonal shifting and other steps. I personally would create a short sound test and submit to ACX without them and see what they say. They’re not bashful and if they complain about lip smacking or tongue popping, then yes, you’re stuck.
That’s my problem. I can create Academy Award® winning lip smacks. Doesn’t matter what my voice does.
https://forum.audacityteam.org/t/how-to-send-a-test-to-acx/49588/1
Koz