Sure! 
I’d venture to say we’re not your typical users.
We work on small VA/VO files for multiple clients at once, and usually record them all in one go. That’s one file, but we separate them out and work on them afterward.
Sometimes one file takes 3 or 4 hours to work on, but another job comes up in the meantime, and it’s a little 10-minute dealie. So we just pop open a 3rd window for that.
Basically we record 3 or 4 scripts, do basic noise reduction and then separate them out into individual files most of the time, which would be 2 working windows, minimum. HOWEVER! It’s not linear work sometimes. Sometimes there’s SFX or screaming, which is handled at the end of the file (so you’re not recording with stripped out cords,) and sometimes we have to shift focus from one active working file to another to meet a deadline.
Occasionally we have to wait for feedback from a client before we can continue to work on their particular file, so we switch to working on a different one so as not to waste time.
Of course we SAVE the projects, but it’s nice to have them all open, so you can just pick up where you left off.
Plus, occasionally, there’s a standard pool of VFX in a file I like to keep open. (I, personally, prefer not to shriek, yell, or scream more than I have to, so I’ve got a decent library of stuff like that, so I don’t have to strip out my vocal cords every time a job says “[angry screeching]”
It’s also handy to have a “Scratch pad” window open so that you can use it to edit 2 or 3 takes together into a good one, (or making a good take out of 2 bad ones on a difficult file,) and you’re not looking back and forth between 7 or 8 takes for the good ones, nor working in an active window with 3 hours of recorded audio. In the scratch pad window, you can jump around easily with Home/End, but in a 3 hour file it becomes a bit easier to lose track of where you are, if you’re zoomed way in, sewing multiple people’s lines together.
When you get moving back and forth from the big, multi-project file, the main working project, and the VFX and scratch-pad windows, and any incidentals, it was handy to have the transport be able to stop another window playing. 
And in all this, I never even THOUGHT of what’d happen if you were recording from, say, a tape deck in the background. 