Select a large shlog (techincal term) of clean room tone. Now select a tiny portion of show and paste only that portion of room tone that fits in the show. Duration of the show does not change. Do this completely automatically without knowing the fine details of in and out points and timing, etc.
Yes.
But also, if you want to replace a long section, Paste will loop the copied audio to fit the space. This means that copying just a few seconds of room tone should be plenty - no need to fill your RAM with an hour of room tone.